{"id":1520,"date":"2025-09-11T16:03:39","date_gmt":"2025-09-11T09:03:39","guid":{"rendered":"https:\/\/vinabiocare.com.vn\/tong-quan-ve-benh-sa-sut-tri-tue-mat-tri-nho\/"},"modified":"2025-10-17T16:20:38","modified_gmt":"2025-10-17T09:20:38","slug":"tong-quan-ve-benh-sa-sut-tri-tue-mat-tri-nho","status":"publish","type":"post","link":"https:\/\/vinabiocare.com.vn\/en\/overview-of-dementia\/","title":{"rendered":"Overview of Dementia"},"content":{"rendered":"<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Epidemiology:<\/strong> In 2021, an estimated 57 million people worldwide were living with dementia, with more than 60% residing in low- and middle-income countries. Nearly 10 million new cases occur every year. In 2019, dementia imposed a global economic burden of USD 1.3 trillion, approximately 50% of which resulted from informal caregiving (mainly by family members and close friends), who on average provide 5 hours of care and supervision daily. Dementia is currently the seventh leading cause of death worldwide and a major cause of disability and dependency among older adults. Dementia results from a wide variety of brain diseases and injuries, with Alzheimer\u2019s disease (AD) being the most common form, accounting for 60\u201370% of all cases.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Definition:<\/strong> Dementia refers to a group of conditions that affect memory, thinking, and the ability to perform daily activities. The disease is progressive over time, primarily affecting older adults, though it is not a normal part of aging. Dementia is a syndrome caused by different pathological processes that progressively destroy neurons and damage the brain, leading to cognitive decline beyond what can be attributed to normal biological aging. While consciousness is not affected, cognitive decline is often accompanied\u2014or sometimes preceded\u2014by changes in mood, emotional regulation, behavior, or motivation.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Dementia has profound physical, psychological, social, and economic impacts\u2014not only for people living with the disease but also for caregivers, families, and society at large. Limited awareness and understanding often lead to stigma, delayed diagnosis, and barriers to care.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Risk factors include:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Aging (more common in individuals aged 65+)<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Hypertension<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Diabetes<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Overweight or obesity<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Smoking<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Excessive alcohol use<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Physical inactivity<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Social isolation<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Depression<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Signs and Symptoms:<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Early changes in mood or behavior may occur before memory problems become apparent. Symptoms worsen progressively, and most people with dementia will eventually require assistance with daily activities. Early symptoms include:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Forgetting recent events or objects<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Misplacing or losing belongings<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Getting lost while walking or driving<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Confusion, even in familiar places<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Losing track of time<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Difficulty solving problems or making decisions<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Trouble following conversations or finding words<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Difficulty completing familiar tasks<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Misjudging distances or visual perception<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Behavioral and mood changes may include:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Anxiety, sadness, or anger related to memory loss<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Personality changes<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Inappropriate behaviors<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Withdrawal from work or social activities<\/span><\/li>\n<li><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Reduced empathy toward others<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">The course of dementia varies by underlying cause, coexisting health conditions, and the individual\u2019s baseline cognitive function. Symptoms usually worsen over time, requiring increased support. In advanced stages, patients may fail to recognize loved ones, have mobility difficulties, lose bladder and bowel control, struggle with eating, or develop distressing behavioral changes such as aggression.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>Progression:<\/strong><\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\">Dementia typically develops over a long preclinical phase. It may take 15\u201330 years for amyloid-\u03b2 (A\u03b2) accumulation to cause the clinical symptoms of AD. Since current interventions target the early stages of AD, pre-symptomatic diagnosis is critical. In the search for urinary biomarkers, researchers have identified fragments of A\u03b2 and amyloid precursor protein (A\u03b2PP) in urine, showing potential as novel biomarkers for mild cognitive impairment (MCI) and dementia. To address the lack of early screening tools for MCI\/dementia, a colloidal gold urine strip test was developed using monoclonal antibodies and phagocytosis-promoting peptides targeting A\u03b2PP and A\u03b2 fragments, and its potential for early detection was evaluated.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><strong>One Step Dementia Risk Test Kit<\/strong> is a screening tool designed to detect the risk of dementia (including but not limited to Alzheimer\u2019s disease). It qualitatively analyzes biochemical markers of amyloid-\u03b2 protein in human urine, providing physicians with supportive evidence to determine whether further testing is required, as well as assisting in monitoring disease progression and treatment outcomes related to brain health.<\/span><\/p>\n<p><span style=\"font-family: 'times new roman', times, serif; font-size: 14pt;\"><em>Reference: World Health Organization. Dementia [Internet]. Geneva: WHO; Updated 31 March 2025 [cited 2025 Jul 12]. Available from: <a class=\"in-cell-link\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/dementia\" target=\"_blank\" rel=\"noopener\">https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/dementia<\/a>.<\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epidemiology: In 2021, an estimated 57 million people worldwide were living with dementia, with more than 60% residing in low- and middle-income countries. Nearly 10 million new cases occur every year. In 2019, dementia imposed a global economic burden of USD 1.3 trillion, approximately 50% of which resulted from informal caregiving (mainly by family members [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":582,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[69],"tags":[],"class_list":["post-1520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-expertise"],"acf":[],"_links":{"self":[{"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/posts\/1520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/comments?post=1520"}],"version-history":[{"count":3,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/posts\/1520\/revisions"}],"predecessor-version":[{"id":1523,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/posts\/1520\/revisions\/1523"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/media\/582"}],"wp:attachment":[{"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/media?parent=1520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/categories?post=1520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vinabiocare.com.vn\/en\/wp-json\/wp\/v2\/tags?post=1520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}